Cayuse 424

Federal Grant Proposals Simplified

Cayuse 424 is the de facto industry standard for fast, accurate completion and submission of federal grant proposals. Premiere research institutions nationwide complete more than 15,000 online proposal submissions annually with the confidence of ISO 27001 certified information security. With deployments in 6 weeks and Evisions renowned ease of use, Cayuse 424 users enjoy improved proposal success and a rapid return on investment – backed by the best customer support in the industry.

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Full Support for Federal Grants

System-to-system submission for grants posted by NIH, NSF, AHRQ, CDC, NIFA, ONR, and other federal agencies, with full support for over 99% of and opportunities.

99% First-Time Submission Success

Get submissions right the first time with the Cayuse 424’s advanced validation engine, which delivers over 1,500 real-time error checks for a 99% first-time success rate.

Real-Time Budget Access

Create budgets online for federal and non-federal proposals and gain real-time access to budget information without emailing documents. Auto-escalation & auto-calculation features simplify planning and tracking of current & future budgets.

Streamline Multi-Project Proposals

Improve efficiency by streamlining the process of creating, reviewing, and submitting complex grants with an unlimited number of components.


Seamless Data Sharing

Simplify research administration by seamlessly sharing data between the Evisions Research Suite and your existing institutional business applications and eRA systems.


ISO 27001 Certified

Secure anytime, anywhere access delivered over a secure online connection from the only eRA provider with ISO 27001 vendor certification – so you know your data is always safe!

Quick deployment in 6 weeks or less over secure browser connection


Full support for 99% of opportunities on and


First-time submission success rate

Over 15,000 proposals submitted through Cayuse 424 each year

Submit Successfully

Make sure your submissions to, and the sponsoring agency are received successfully on the first attempt. Cayuse 424 features an Advanced Validation Engine that ensures a 99% first-time success rate for all system-to-system submissions. During proposal development, the system performs real-time error checks for agency- and opportunity-specific rules, and validations, and other business rules. Error warnings include hyperlinks to help you quickly resolve issues and submit error-free proposals every time.

Reduce Repetition

Eliminate as much data entry as possible and improve accuracy with Cayuse 424 Auto-Fill capabilities. Cayuse 424 stores institutional and personnel data, so when a proposal is created, information is conveniently pre-populated within the proposal or auto-filled from drop-down menus. Auto-Fill data includes biographical information, department and institutional information (such as DUNS # and addresses), plus rate and salary information for simplifying budget creation.

Subaward Automation Improves Accuracy

Eliminate the error-prone challenge of manually folding subaward proposals and budgets into prime proposals. The Import Subaward feature ensures any changes made to a Subaward automatically get carried forward to the prime proposal. Automation offers greater assurance of data accuracy when developing complex proposals that include one or more subawards.

Connect Critical Data in Real Time to External Systems

Improve research efficiency, data accuracy, and compliance throughout the entire research project life cycle. Cayuse 424 APIs simplify post-award management, creating a bi-directional data exchange of proposal information with existing eRA systems. Cayuse Connect modules maintain a single, accurate version of your most important data by integrating Cayuse 424 with institutional business applications.

API Connect provide easy integration into post-award systems, preserving the value of your investment and reducing administrative tasks. With bi-directional data exchange of proposal information with existing eRA systems, you can maintain capital expenses and expedite S2S submissions to federal funding agencies.

Cayuse Connect modules – HR Connect, Data Connect and SSO Connect – provide integration with Enterprise Resource Planning (ERP), Data Warehouse and Authentication systems, improving efficiency, data accuracy, and compliance throughout the entire project life cycle.

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Easy Access to Proposal Budgets

Create budgets online for federal and non-federal proposals with Cayuse 424. Your research team has real-time access to budget information in a single system, without the need for additional tools and spreadsheets. With proposal and budgeting information available in a single place, research administrators can keep better track of components for easy reference and improved accuracy.

Secure, Convenient Storage

Easily attach documentation for a specific project when submitting required files to and Cayuse 424 stores all source documents (e.g. the Word version of the PDF) and provides secure, online access to supporting files. With all proposal-related files stored within Cayuse 424, users can easily view, route or print complete proposal documentation conveniently from any location at any time.

Resubmit Without Duplicating Entries

Repurpose large amounts of proposal information quickly and easily with the Copy/Transform function. All it takes is a button click to eliminate duplicate data entry and save you time.

Copy an entire proposal for re-submission without duplicating data. Quickly turn revised proposals to meet each funding cycle deadline.

Transform a proposal from one opportunity to another by transferring existing data to a different opportunity, or a new version of the same opportunity, including any information or forms that remain the same. Repurposing information from one opportunity to another allows institutions to increase their number of proposal submissions.


See What Our Clients Have to Say

“Cayuse 424 is simply the best, most intuitive proposal preparation software available. I do essentially no training for PIs. Rarely do we encounter an announcement that is unavailable through Cayuse 424.”

Bill Caskey

Director of Sponsored Research, Texas Biomedical Research Institute

“Compared to submission through, it is a dream and next to FastLane the best portal for submission I’ve seen. The features for transforming proposals make it easy on PIs, the built in error warning bar gives confidence that last minute submissions will make it through.”

Mary Hensel

Office of Research Development, University of Massachusetts Dartmouth

Contact Us

Call 888.533.5993 | Email